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刘晓玲

作者:         来源:         发布日期:2022-12-15     浏览次数:

     

一、个人简介

刘晓玲,女,汉族,生于1985年11月,河北石家庄人,青年教授,博士生导师。入选西北农林科技大学“高层次人才发展支持计划”青年拔尖人才B1岗。

二、学习与工作经历

1. 学习经历

2005.09-2009.06 河北大学 化学与材料科学学院  理学学士

2010.09-2013.06 河北大学 化学与材料科学学院  理学硕士

2013.09-2018.06 中国科学院生态环境研究中心   理学博士

2. 工作经历

2018.09-2022.11 陕西师范大学 化学化工学院  博士后

2022.12至今 西北农林科技大学 化学与药学院  青年教授

三、研究课题

1. 国家自然科学基金面上项目(22474111,2025-2028),主持

2. 西北农林科技大学引进人才启动经费(2023-2027),主持

3. 国家自然科学基金青年基金项目(22104077,2022-2024),主持

4. 陕西省自然科学基金青年项目(2020JQ-407,2020-2021),主持

5. 中央高校基本科研业务费(GK202103044,2021-2022),主持

6. 中央高校基本科研业务费(GK201903047,2019-2020),主持

四、研究领域

1. 生化分析与分子诊断

2. 细胞成像、RNA成像

3. 生化传感与基因调控

五、开设课程

为本科生讲授《细胞生物学》、《工程化学》等课程。

六、主要科研成果与学术论文

1.Xiaoling Liu#, Weiyi Lai#, Yao Li#, Shaokun Chen, Baodong Liu, Ning Zhang, Jiezhen Mo, Cong Lyu, Jing Zheng, Ya-Rui Du, Guibin Jiang, Guo-Liang Xu, Hailin Wang*. N6-methyladenine is incorporated into mammalian genome by DNA polymerase. Cell Research 2021, 31, 94–97.

2. Zuzhe Kang, Yue Zhou, Wenji Wang, Simin Wang, Shenghao Wen, Huixin Yu, Xiaoling Liu*, Jinyi Wang*, Mao-Sen Yuan*. Dual-response chemosensor for monitoring changes of polarity and •OH in ferroptosis of cell and zebrafish. Sensors & Actuators: B. Chemical 2025, 426, 137121.

3. Xinrui Fei, Chao Lei, Wei Ren, Xiaoling Liu*, Chenghui Liu*. Regulating the  trans -cleavage activity of CRISPR/Cas12a by using an elongation-caged single-stranded DNA activator and the biosensing applications. Analytical Chemistry 2023, 95, 12169–12176.

4. Xinyue Kang, Chao Lei, Jingjing Shi, Xiaoling Liu*, Wei Ren, Chenghui Liu*. A versatile CRISPR/Cas12a-based biosensing platform coupled with a target-protected transcription strategy. Biosensors and Bioelectronics 2023, 219, 114801.

5. Xiaoling Liu*, Xinyue Kang, Chao Lei, Wei Ren, Chenghui Liu*. Programming the  trans -cleavage activity of CRISPR-Cas13a by single-strand DNA blocker and its biosensing application. Analytical Chemistry 2022, 94, 3987–3996.

6. Gaoting Wang, Weimin Tian, Xiaoling Liu*, Wei Ren, Chenghui Liu*. New CRISPR-derived microRNA sensing mechanism based on Cas12a self-powered and rolling circle transcription-unleashed real-time crRNA recruiting. Analytical Chemistry 2020, 92, 6702–6708.

7. Xiaoling Liu, Weiyi Lai, Ning Zhang, Hailin Wang*. Predominance of N6-methyladenine-specific DNA fragments enriched by multiple immunoprecipitation. Analytical Chemistry 2018, 90, 5546–5551.

8. Weimin Tian, Xiaoling Liu*, Gaoting Wang, Chenghui Liu*. A hyperbranched transcription-activated CRISPR-Cas12a signal amplification strategy for sensitive microRNA sensing. Chemical Communications 2020, 56, 13445–13448.

9. Gaoting Wang, Wenjiao Fan, Wei Ren, Xiaoling Liu*, Chenghui Liu*. High-sensitive sensing of plant microRNA by integrating click chemistry with an unusual on-bead poly(T)-promoted transcription amplification. Analytica Chimica Acta 2020, 1111, 16–22.

10. Fei Xinrui, Liu Xiaoling*, Liu Chenghui*. The effect of different DNA activator structures on the  trans -cleavage activity of Cas12a for in vitro biosensing. Journal of Instrumental Analysis 2022, 41, 610–617.

11. Guoqiang Zhang#, Hua Huang#, Di Liu#, Ying Cheng, Xiaoling Liu, Wenxin Zhang, Ruichuan Yin, Dapeng Zhang, Peng Zhang, Jianzhao Liu, Chaoyi Li, Baodong Liu, Yuewan Luo, Yuanxiang Zhu, Ning Zhang, Shunmin He, Chuan He, Hailin Wang*, Dahua Chen*. N6-Methyladenine DNA modification in Drosophila. Cell 2015, 161, 893–906.

12. Rong Miao, Jing Li, Chao Wang, Xuefeng Jiang, Ying Gao, Xiaoling Liu, Dan Wang, Xin Li, Xiaogang Liu*, and Yu Fang*. A general method to develop highly environmentally sensitive fluorescent probes and AIEgens. Advanced Science 2022, 9, e2104609.

13. Baodong Liu, Xiaoling Liu, Weiyi Lai, Hailin Wang*. Metabolically generated stable isotope-labeled deoxynucleoside code for tracing DNA N6-methyladenine in human Cells. Analytical Chemistry 2017, 89, 6202–6209.

14. Hui Wang, Honghong Wang, Yuanyuan Sun, Xiaoling Liu, Ye Liu, Chengli Wang, Pengbo Zhang, Zhengping Li*. A general strategy for highly sensitive analysis of genetic biomarkers at single-base resolution with ligase-based isothermally exponential amplification. Talanta 2020, 212, 120754–120761.

15. Weimin Tian, Gaoting Wang, Xiaoling Liu, Wei Ren, Chenghui Liu*, Zhengping Li*. A terminal extension-actuated isothermal exponential amplification strategy toward the ultrasensitive and versatile detection of enzyme activity in a single cell. Talanta 2020, 211: 120704–120709.

七、联系方式

通讯地址:西北农林科技大学(北校区)化学与药学院

邮编:712100

邮箱:liuxiaoling@nwafu.edu.cn

课题组科研条件良好,成员朝气蓬勃,科研氛围活跃。热忱欢迎对化学生物学、分析化学、分子生物学学科感兴趣的博士、硕士研究生以及本科生加入课题组,一起探寻科研奥秘!热忱欢迎从事分子诊断、细胞成像、生物医药研究等相关领域的博士合作开展博士后研究工作。

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