一、个人简介
王俊儒，男，汉族，生于1966年11月，陕西杨凌人，中共党员，教授，博士生导师。省教学名师奖、校首届金牌教师卓越奖获得者，兼任省化学会理事、省教指委委员、校研究生教学督导、全国教创赛和省职教赛评委，2次赴英国留学。曾获杨凌农业高新产业示范区十大杰出青年称号，入选教育部“新世纪优秀人才支持计划”。
二、学习与工作经历
1.学习经历
1983.9-1987.6年获兰州大学有机化学学士学位；
1996年7月在职获西北农林科技大学土壤学硕士学位；
2001年7月在职获西北农林科技大学植物营养学博士学位；
1994年9月至1995年2月，在中科院成都生物所进修植物化学，从事天然产物化学研究。
2.工作经历
1987年6月-至今，在本校从事有机化学教学及天然药物资源化学研究。
2001年10月-2002年10月受国家留学基金委资助以普访身份在英国洛桑试验站从事环境生物学研究
2010年10月至2011年9月受国家留学基金委资助以高访身份在英国洛桑试验站从事化学生物学研究。
三、研究课题
1.功能食品（新资源食品）及保健品研制（横向课题），2024.05-2024.12
2.β-咔啉二聚体药物合成工艺策略及潜在应用，科技部国家外国专家项目，2020.12-2021.12
3.两亲性β-咔啉二聚体DNA嵌插剂的设计合成、抗肿瘤活性及作用机制，国家自然基金面上项目，No.81773603，2018.1-2021.12
4.基于骆驼蓬生物碱为模板的β-咔啉类的二聚化合成、抗癌活性及其机理研究，国家自然基金面上项目，No.31270388，2013.1-2016.12
5.有机枸杞精深加工技术研发和服务（横向课题），2017.06–2022.06
四、研究领域
1.高活性天然分子产物结构修饰与靶向设计。
2.药用植物资源化学与特殊天然产物生产技术。
五、开设课程和教学成果
为本科讲授英文《有机化学》、《有机化学》、《有机化学实验》和暑期课程全英文《生命与有机化学，Life & Organic Chemistry》课程，为研究生讲授《制药分离工程》、全英文《高等有机化学》等。
积极推进以能力和素质培养为中心的高等农林院校有机化学教育改革，主持国家级首批线上课程有机化学1门。主参编国家规划教材4本，获省部优秀教材奖6本（次），省级教学成果奖4项。
六、主要科研成果与学术论文
主要从事药用植物资源化学、高活性天然产物生物功能研究，培养博硕士110名，发表等发表天然产物资源化学与功能分子研究论文180余篇。
1. Dongming Zhi, Zhiyuan An, Lishan Li, et al. 3-Amide-β-carbolines block the cell cycle by targeting CDK2 and DNA in tumor cells potentially as anti-mitotic agents, Bioorganic Chemistry, 2024, 145, 107216
2. Youwei Du, Huiya Ma, Yuanyuan Liu, et al. Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry. New Phytologist，2024, 242:558–575
3. Chongyang Wang, Ting Wang, Jiangkun Dai, et al. Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways，Poultry Science，2024, 103(9):103944
4. Xu, Y.; Li, L.; Zhang, J.; et al. Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates. Molecules， 2024, 29, 3569.
5. Wang, Chongyang, Hu, Ruochen, Wang, Ting et al. A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A, J Biol Chem, 2023,299(4),104605
6. Dan, Wenjia; Gao, Jixiang; Zhang, Jiaoyue et al. Antibacterial activity and mechanism of action of canthin-6-one against Staphylococcus aureus and its application on beef preservation, Food Control, 2023, 147: 109604.
7. Wang, Chongyang，Ting Wang, Ruochen Hu, et al. 9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3b and HSP90b. Journal of Virology，2023，97(3),
8. Xue Yang, Xi Zhou, Lei Li, et al. Large-Area Black Phosphorus/PtSe2 Schottky Junction for High Operating Temperature Broadband Photodetectors，Small, 2023,2206590
9. Ma H, Yu H, Li Z, et al. β-Carboline dimers inhibit the tumor proliferation by the cell cycle arrest of sarcoma through intercalating to Cyclin-A2. Front Immunol. 2022，13:922183
10. Dan W, Gao J, Qi X, et al. Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism. EJMC. 2022，243:114765
11. Guo-ku Liu，Tai-xin Yang，Jun-ru Wang，Polysaccharides from Polyporus umbellatus: A review on their extraction, modification, structure, and bioactivities. IJBM 2021,189:124–134
12. Chongyang Wang, Ting Wang, Jiangkun Dai et al. 1-Formyl-β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes, Biomolecules 2021, 11(11), 1687
13. Chongyang Wang, Ting Wang, et al. Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity. Frontiers in Microbiology, 2020, 11:987;
14. Jiangkun Dai，Rui Han，Yujie Xu，et al. Recent progress of antibacterial natural products: future antibiotics candidates，Bioorganic Chemistry 2020,101:103922
15. Na Li, Jiang-Kun Dai , Dan Liu, et al. Synthesis and in vitro Antibacterial Activity of Quaternization 10-Methoxycanthin-6-one Derivatives. Molecules 2019, 24, 1553
16. Sileshi G Wubshet, Bingrui Liu, Kenneth T Kongstad, et al. Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complimentary inhibition and affinity profiles. Talanta，2019,200:279-287
17. Qiu, R. Y., J. R. Wang, and K. L. Parkin. 2018. Activity-guided isolation of phase II enzyme inducers from buckwheat flour methanolic extracts, J Sci Food Agric. 2018,98:4911–18
18. Zhang, Dan, Na Li, Yiming Ma, Ruixue Wang, Jinyi Wang, and Junru Wang. New strategy for the azido–ascorbic acid reaction: a convenient chemosensor and its imaging in garlic slice tissues, New Journal of Chemistry, 2018，42: 6707-12.
19. Dai, J., W. Dan, N. Li, R. Wang, et al. Synthesis and antibacterial activity of C(2) or C(5) modified and D ring rejiggered canthin-6-one analogues, Food Chem, 2018，253: 211-20
20. Jiangkun Dai, Wenjia Dan, Na Li, Junru Wang. Computer-aided drug discovery: Novel 3,9-disubstituted eudistomin U derivatives as potent antibacterial agents, EJMC, 2018,157, 333-338
21. Jiangkun Dai, Wenjia Dan, Uwe Schneider, Junru Wang. β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities, EJMC, 2018, doi：10.1016/j.ejmech.2018.08.027
22. Dan-Dan Tang, Yao Wang, Jun-Ru Wang, Peng-Fei Xu. Phosphine-Mediated Synthesis of Trifluoromethyl Substituted Pyrroles Using TFAA as the CF3 Source. Tetrahedron Letters, 2014, 55(30):4133–4135.
23. Na Li, Jiang-Kun Dai, Hong-Tao Du, et al. β-Carboline Functionalized Dithioacetal as Hg2+ Selective Fluorescence Probe in Water. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015,136: 900–905
24. Rongying Qiu, Junru Wang, Kirk L Parkin. Isolation and identification of potential cancer chemopreventive agents from nonpolar extracts of buckwheat flour. Food Research International, 2014, 66: 86-92.
25. Li Ding, Hai Yu, Kam Lau, Saddam Muthana, Junru Wang, Xi Chen. Efficient chemoenzymatic synthesis of sialyl Tn-antigen and derivatives. Chem Commun, 2011, 47, 8691-8693
26. Junru Wang, Fang-Jie Zhao, Andrew A. Meharg, Andrea Raab, Joerg Feldmann, Steve P. McGrath. Mechanisms of Arsenic Hyperaccumulation in Pteris vittata. Uptake Kinetics，Interactions with Phosphate，and Arsenic Speciation. Plant Physiology， 2002. 130: 1552-561
七、联系方式
通讯地址：西北农林科技大学（北校区）化学与药学院C206室
邮编：712100
电话：15109273921
邮箱：wangjunru@nwsuaf.edu.cn, wangjr07@163.com
