涂琴，女，1987年3月出生，博导，教授
受教育经历
2008/09-2013/06，西北农林科技大学，理学院，博士
2008/09-2013/06，西北农林科技大学，理学院，学士
工作经历
2024/01-至 今，西北农林科技大学化学与药学院，教授
2016/01-2023/12，西北农林科技大学化学与药学院，副教授
2017/12-2018/12，美国马萨诸塞大学，访问学者
2013/07-2015/12，西北农林科技大学理学院，讲师
研究方向
功能材料制备；仿生界面构建和生物学应用；生命分析化学
代表性研究成果（# 并列第一，* 通讯作者）
[1]Yuanxiang Jing, Ting Huang, Bin Zhao, Li Zhao, Nannan Zhang, Kexin Zhang,Keke Wang, Jinyi Wang*, Jinlian Hua*, Qin Tu*. A ROS/glucose stimulated-responsive ADSCs-derived exosomes-release hydrogel system for diabetic wound healing. Chemical Engineering Journal, 2024, 487:150561.
[2]Ting Huang, Yingbing Zhang, Li Zhao, Yu Ren, Keke Wang, Nannan Zhang,Xiaoli Zhang, Jinyi Wang, Qin Tu*. Sodium hyaluronate hydrogel for wound healing and human health monitoring based on deep eutectic solvent. International Journal of Biological Macromolecules, 2024, 257:128801.
[3]Meng Zhang, Jianhong Zhang, Xin Che, Jingjing Jiang, Qin Tu*, Jinyi Wang*. Biomimetic mineralization-based In situ growth of AuNCs@ZIF-8 on paper fibers for visual detection of copper ions. Talanta, 2024, 268:125364.
[4]Zuzhe Kang#, Jingjing Jiang#, Qin Tu#, Shuaiting Liu, Yue Zhang, Dong-En Wang*, Jinyi Wang*, Mao-Sen Yuan*. Dual-Site chemosensor for monitoring ·OH-cysteine redox in cells and in vivo. Journal of the American Chemical Society, 2023, 145:507-515.
[5] Yu Ren, Ting Huang, Xinyao Zhao, Keke Wang, Li Zhao, Anju Tao, Jingjing Jiang, Maosen Yuan*, Jinyi Wang*, Qin Tu*. Double network hydrogel based on curdlan and flaxseed gum with photothermal antibacterial properties for accelerating infectious wound healing. International Journal of Biological Macromolecules, 2023, 242:124715.
[6] Yajuan Deng, Tianbao Li, Qin Tu*, JinyiWang*. Highly stretchable and self-adhesive ionically cross-linked double-network conductive hydrogel sensor for electronic skin. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 656:130363.
[7] Lingtong Zhou, Yuanchang Li, Qin Tu*, Jinyi Wang*. A 3D printing mold method for rapid fabrication of artificial blood vessels. Colloids and Surfaces A: Physicochemical and Engineering Aspects 662 (2023) 130952.
[8] Yu Ren, Aili Ailierken, Li Zhao, Zhuangsheng Lin, Jingjing Jiang, Balun Li, Jinyi Wang*, Jinlian Hua*, Qin Tu*. hUC-MSCs lyophilized powder loaded polysaccharide ulvan driven functional hydrogel for chronic diabetic wound healing. Carbohydrate Polymers, 2022, 288:119404.
[9] Wenkun Zhang, Ting Huang, Yu Ren, Shuai Yang, Xinyao Zhao, Maosen Yuan*, Jinyi Wang*, Qin Tu*. A multifunctional chitosan composite aerogel for PPCPs adsorption. Carbohydrate Polymers, 2022, 298:120102.
[10] Zuzhe Kang, Jiao Yang, Jingjing Jiang, Li Zhao, Yanrong Zhang, Qin Tu*, Jinyi Wang*, Mao-Sen Yuan*. Pillar[5]arenes modified tetraphenylethylene as fluorescent chemosensor for paraquat detection. Sensors and Actuators: B. Chemical, 2022, 370:132436.
[11] Jiao Yang, Shu-Wei Chen, Bingwen Zhang, Qin Tu*, Jinyi Wang*, Mao-Sen Yuan*. Non-biological fluorescent chemosensors for pesticides detection. Talanta, 2022, 240: 123200.
[12] Yilei Wang, Yingbing Zhang, Zhuangsheng Lin, Ting Huang, Wen Li, Wanxin Gong, Yuhui Guo, Jianmin Su, Jinyi Wang*, Qin Tu*. A green method of preparing a natural and degradable wound dressing containing aloe vera as an active ingredient. Composites Part B-Engineering, 2021, 222:109047.
[13] Yadan Guo, Yi Luo, Minggen Tang, Meng Zhang, Mao-sen Yuan, Shuwei Chen, Qin Tu*, Jinyi Wang*. Gold nanosensor for the selective identification of Escherichia coli in foodstuff and its antibacterial ability. Sensors and Actuators: B. Chemical, 2021, 34:130191.
[14] Bo Gao, Guoqiang Li, Lingtong Zhou, Yan Guo, Qin Tu*, Jinyi Wang*. On-chip screening of chemically induced mutant strains and assay of their metabolites by liquid chromatography tandem mass spectrometry. Sensors and Actuators: B. Chemical, 2021, 348:130655.
[15] Wen Li, Xinyao Zhao, Ting Huang, Yu Ren, Wanxin Gong, Yuhui Guo, Jinyi Wang*, Qin Tu*. Preparation of sodium hyaluronate/dopamine/AgNPs hydrogel based on the natural eutetic solvent as an antibaterial wound dressing. International Journal of Biological Macromolecules, 2021,191, 60-70.
[16] Wenkun Zhang, Ting Huang, Yu Ren, Yilei Wang, Ruijin Yu, Jinyi Wang*, Qin Tu*. Preparation of chitosan crosslinked with metal-organic framework (MOF-199)@aminated graphene oxide aerogel for the adsorption of formaldehyde gas and methyl orange. International Journal of Biological Macromolecules, 2021, 193: 2243-2251.
[17] Qingmiao Zhang, Zhuangsheng Lin, Wenkun Zhang, Ting Huang, Jingjing Jiang, Yu Ren, Ruiqi Zhang, Wen Li, Xiaoli Zhang*, Qin Tu*.
Fabrication of green poly(vinyl alcohol) nanofibers using natural deep eutectic solvent for fast-dissolving drug delivery. RSC Advance, 2021, 11, 1012.
[18] Yilei Wang, Yingbing Zhang, Jianmin Su, Xiaoli Zhang, Jinyi Wang*, Qin Tu*. Preparation of multifunctional wound dressing based on a natural deep eutectic solvent. Acs Sustainable Chemistry & Engineering, 2020, 37:14243-14252.
[19] Qin Tu, Zhuangsheng Lin, Jinning Liu, Haochen Dai, Tianxi Yang, Jinyi Wang, Eric Decker, David Julian McClements, Lili He*.
Multi-phase detection of antioxidants using surface-enhanced Raman spectroscopy with a gold nanoparticle-coated fiber. Talanta, 2020, 206:120197.
[20] Yufeng Zhang#, Qin Tu#, Long Chen, Na Li, Liu Yang, Xiaoxue Zhang, Mao-Sen Yuan*, Jinyi Wang*.
A fluorescein-based AND-logic FPSi probe for the simultaneous detection of Hg2+ and F−. Talanta, 2019, 202:323–328.
[21] Qingmiao Zhang, Yilei Wang, Wenkun Zhang, Michael E. Hickey, Zhuangsheng Lin, Qin Tu*, Jinyi Wang. In situ assembly of well-dispersed Ag nanoparticles on the surface of polylactic acid-Au@polydopamine nanofibers for antimicrobial applications. Colloids and Surfaces B: Biointerfaces, 2019, 184:110506.
[22] Qin Tu, Michael E. Hickey, Tianxi Yang, Siyue Gao, Qingmiao Zhang, Yanqi Qu, Xinyi Du, Jinyi Wang, Lili He*.
A simple and rapid method for detecting the pesticide fipronil on egg shells and in liquid eggs by Raman microscopy.
Food Control, 2019, 96:16–21.
[23] Xiang Liu, Lingtong Zhou, Peng Heng, Jingcheng Xiao, Junping Lv, Qingmiao Zhang, Michael E. Hickey, Qin Tu*, Jinyi Wang*. Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement. Colloids and Surfaces B: Biointerfaces, 2019, 175:264–271.
[24] Qin Tu*, Qingmiao Zhang, Yilei Wang, Ying Jiao, Jingcheng Xiao, Tangqiong Peng, Jinyi Wang. Antibacterial properties of poly(dimethylsiloxane) surfaces modified with graphene oxide-catechol composite. Progress in Organic Coatings, 2019, 129:247–253.
[25] Qin Tu, Tianxi Yang, Yanqi Qu, Siyue Gao, Zhiyun Zhang, Qingmiao Zhang, Yilei Wang, Jinyi Wang, Lili He*. In situ colorimetric detection of glyphosate on plant tissues using cysteamine-modified gold nanoparticles.
Analyst, 2019, 144:2017–2025.
[26] Jianping Guan#, Qin Tu#, Long Chen, Mao-Sen Yuan*, Jinyi Wang*. A benzothiazole-rhodol based luminophor: ESIPT-induced AIE and an application for detecting Fe2+ ion. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 2205:117114.
[27] Qingmiao Zhang,Qin Tu*, Michael E. Hickey, Jingcheng Xiao, Bo Gao, Chang Tian, Peng Heng, Ying Jiao, Tangqiong Peng, Jinyi Wang. Preparation and study of the antibacterial ability of graphene oxide-catechol hybrid polylactic acid nanofiber mats. Colloids and Surfaces B: Biointerfaces, 2018, 172:496–505.
[28] Qin Tu, Chang Tian, Tongtong Ma, Long Pang, Jinyi Wang*.
Click synthesis of quaternized poly(dimethylaminoethyl methacrylate) functionalized graphene oxide with improved antibacterial and antifouling ability. Colloids and Surfaces B: Biointerfaces, 2016, 141:196–205.
[29] Qin Tu, Chao Ma, Chang Tian, Maosen Yuan, Xiang Han, Dong-En Wang, Chenyu Cao, Jinyi Wang*.
Quantum dots modified with quaternized poly(dimethylaminoethyl methacrylate) for selective recognition and killing of bacteria over mammalian cells, Analyst, 2016, 141:3328–3336.
[30] Qin Tu, Lei Zhao, Xiang Han, Dong-En Wang, Maosen Yuan, Chang Tian, Jinyi Wang*. A visualized method for Cu2+ ions detection by self-assembling azide functionalized free graphene oxide using click chemistry, RSC Advance, 2016, 6:95628–95632.
[31] Qin Tu, Long Pang, Yun Chen, Yanrong Zhang, Rui Zhang, Binzhang Lu, Jinyi Wang*. Effects of surface charges of graphene oxide on neuronal outgrowth and branching. Analyst, 2014, 139:105–115.
[32] Qin Tu, Long Pang, Lingli Wang, Yanrong Zhang, Rui Zhang, Jinyi Wang*. Biomimetic choline-like graphene oxide composites for neurite sprouting and outgrowth. ACS Applied Materials & Interfaces, 2013, 5:13188–13197.
[33] Qin Tu, Jian-Chun Wang, Rui Liu, Juan He, Yanrong Zhang, Shaofei Shen, Juan Xu, Jianjun Liu, Maosen Yuan, Jinyi Wang*.
Antifouling properties of poly(dimethylsiloxane) surfaces modified with quaternized poly(dimethylaminoethyl methacrylate). Colloids and Surfaces B: Biointerfaces, 2013, 102:361–370.
[34] Qin Tu, Jian-Chun Wang, Rui Liu, Yanrong Zhang, Juan Xu, Jianjun Liu, Mao-Sen Yuan, Wenming Liu, Jinyi Wang*.
Synthesis of polyethylene glycol- and sulfobetaine-conjugated zwitterionic poly(l-lactide) and assay of its antifouling and antimicrobial properties. Colloids and Surfaces B: Biointerfaces, 2013, 102:331–340.
[35] Qin Tu, Jian-Chun Wang, Rui Liu, Yun Chen, Yanrong Zhang, Dong-En Wang, Mao-Sen Yuan, Juan Xu, Jinyi Wang*. Click synthesis of neutral, cationic, and zwitterionic poly(propargyl glycolide)-co-poly(ɛ-caprolactone)-based aliphatic polyesters as antifouling biomaterials. Colloids and Surfaces B: Biointerfaces, 2013, 108:34–43.
[36] Jian-Chun Wang, # Qin Tu, # Yaolei Wang, Wenming Liu, Rui Liu, Shaofei Shen, Juan Xu, Lei Zhao, Jinyi Wang*. Pneumatic mold-aided construction of a three-dimensional hydrogel microvascular network in an integrated microfluidics and assay of cancer cell adhesion onto the endothelium. Microfluidics and Nanofluidics, 2013, 15:519–532.
[37] Qin Tu, Long Pang, Yanrong Zhang, Mao-Sen Yuan, Jian-Chun Wang, Dong-En Wang, Wenming Liu, Jinyi Wang*.
Microfluidic device: a miniaturized platform for chemical reactions. Chinese Journal of Chemistry, 2013, 31:304–316.
[32] Nan Nie, # Qin Tu, # Jian-Chun Wang, Fan Chao, Rui Liu, Yanrong Zhang, Wenming Liu, Jinyi Wang*. Synthesis of copolymers using dendronized polyethylene glycol and assay of their blood compatibility and antibacterial adhesion activity. Colloids and Surfaces B: Biointerfaces, 2012, 97:226–235.
[38] Qin Tu, Yanrong Zhang, Rui Liu, Li Li, Nan Nie, Ajing Liu, Lei Wang, Wenming Liu, Li Ren, Xueqin Wang, Jinyi Wang*. Active drug targeting of disease by nanoparticles functionalized with ligand to folate receptor. Current Medicinal Chemistry, 2012, 19:3152–3162.
[39] Qin Tu, Jian-Chun Wang, Yanrong Zhang, Rui Liu, Wenming Liu, Li Ren, Shaofei Shen, Juan Xu, Lei Zhao, Jinyi Wang*. Surface modification of poly(dimethylsiloxane) and its applications in microfluidics-based biological analysis. Reviews in Analytical Chemistry, 2012, 31:177–192.
[40] Qin Tu, Li Li, Yanrong Zhang, Jian-Chun Wang, Rui Liu, Manlin Li, Wenming Liu, Xueqin Wang, Li Ren, Jinyi Wang*. The effect of acetylcholine–like biomimetic polymers on neuronal growth. Biomaterials, 2011, 32:3253–3264.
[41] Yanrong Zhang, # Li Ren, # Qin Tu, # Xueqin Wang, Li Li, Jian-Chun Wang, Wenming Liu, Juan Xu, Jinyi Wang*. Fabrication of reversible poly(dimethylsiloxane) surfaces via host–guest chemistry and their repeated utilization in cardiac biomarker analysis. Analytical Chemistry, 2011, 83:9651–9659.
学术荣誉及获奖情况
1. 2023年陕西省化学优秀青年奖。
2. 打造“食源性致病菌即时检测、鉴定及杀灭一站式”平台，助力健康中国的对策研究，科技智库青年人才计划、2022年。
3. 基于微流控芯片高通量快速检测食品基质中的细菌，陕西省高校科协青年人才托举计划、2021年。
4. 基于微流控芯片的生物分析化学新方法研究，陕西省科学技术二等奖、第三完成人、2017年。
5. 功能聚合物界面构建及其在生命分析中的应用，陕西省优秀博士论文、2015年。
专利情况
1. 刘文明，王进义，王建春，许娟，李天保，涂琴，王垚磊. 集成微流控芯片及其用于三维肿瘤定位、构建、回收方法。专利申请号：201410366445.1
2. 王进义，刘文明，涂琴，王建春，张艳荣，许娟，王尧磊，刘瑞，申少飞，赵磊，袁茂森，李天保。一种气动阵列化细胞捕获与释放芯片及其操作方法。专利申请号：201210207999.8
3. 涂琴，任宇，艾力.艾尔肯，王进义，华进联，李雯，黄婷，袁茂森，李天保，许娟。含有人脐带间充质干细胞冻干粉的抑菌水凝胶的制备方法。专利号：ZL 2021 1 0641566.2
4. 涂琴，张文坤，王进义，杨帅，黄婷，任宇，袁茂森，李天保。通过双冰模板法制备ZIF-67/QGO/SB-CS气凝胶的方法及其应用。专利号：ZL 2022 1 0442907.8
5. 涂琴，黄婷，王进义，赵芯垚，任宇，袁茂森，李天保。一种基于天然低共熔溶剂制备用于伤口愈合和人体健康监测的多功能导电水凝胶的方法。专利申请号：202211150825.2
6. 涂琴，王珂珂，赵斌，王进义，袁茂森，余瑞金。通过多模式策略治疗细菌性角膜炎的抑菌水凝胶及其制备方法和应用。专利申请号：202311491783.3
涂琴，任宇，赵斌，赵莉，王进义，袁茂森，李天保，余瑞金。含有L-精氨酸修饰的多金属氧酸盐的双层水凝胶敷料及其制备方法。专利申请号：2023116060798
4) 承担科研项目情况。
① pH调控的循环肿瘤细胞捕获、释放及在线高通量分析微流控芯片，国家自然科学基金，20.0万，2016/01–2018/12，主持。
② 基于表面增强拉曼光谱-微流控芯片的高通量食品基质细菌快速检测，陕西省自然科学基金一般项目，3.0万，2020/01–2021/12，主持。
③ 基于微流控芯片高通量快速检测食品基质中的细菌，陕西省高校科协青年人才托举计划，2.0万，2022/01–2023/12，主持。
④ 打造“食源性致病菌即时检测、鉴定及杀灭一站式”平台，助力健康中国的对策研究，2022年度科技智库青年人才计划，5.0万，2022/07–2022/12，主持。
⑤ 基于SERS的食源性致病菌检测与分型微流控芯片构建与应用，陕西省自然科学基金面上项目，5.0万，2023/01–2024/12，主持。
⑥ 治疗细菌性角膜炎生物凝胶的研究与开发，横向项目，80.0万，2023/11–2024/12，主持。
⑦ 伤口愈合生物凝胶的研究与开发，横向项目，60.0万，2023/10–2026/12，主持。
⑧ 干细胞外泌体用于Ⅱ型糖尿病患者创面愈合，横向项目，20.0万，2022/12–2025/12，主持。
⑨ 具有抑菌活性的生物材料的制备，横向项目，7.0万，2019/06–2019/12，主持。
⑩ 伤口敷料凝胶，横向项目，5.0万，2020/06–2022/06，主持。
⑪ 功能聚合物制备及其生物学应用，陕西省优秀博士学位论文资助，6.0万，2013/01–2017/12，主持。
⑫ pH调控的循环肿瘤细胞捕获、释放及在线分析，中央高等学校基本科研-创新一般项目，10.0万，2014/01–2017/12，主持。
⑬ 循环肿瘤细胞捕获与成像纳米传感构建，西北农林科技大学博士科研启动基金，5.0万，2014/01–2015/12，主持。
联系方式：
通讯地址：陕西杨凌西北农林科技大学化学与药学院
邮编：712100
邮箱：tuqin@nwsuaf.edu.cn
