一、个人简介
许元真，女，汉族，生于1988年7月，河南洛阳人，硕士生导师。
二、学习与工作经历
1.学习经历
2010.9-2015.6 兰州大学 理学博士学位
2006.9-2010.6 郑州大学化学系 理学学士学位
2.工作经历
2015.7-至今 西北农林科技大学理学院/化学与药学院
三、研究课题
1.主持国家自然科学基金青年项目一项（No.81602994）
2.主持西北农林科技大学科研启动基金一项（Z109021619）
3.主持陕西省自然科学基金青年项目一项（2019JQ-636）
4.主持陕西省专项配套经费一项
四、研究领域
1.天然产物中具有神经营养、神经保护和抗神经炎作用的先导化合物的发现；
2.天然活性成分的合成、结构改造与构效关系研究；
3.高活性先导化合物的作用机制研究。
五、开设课程
为本科生讲授《无机及分析化学》、《药物化学》、《工程化学》等理论和实验课程
六、主要科研成果与学术论文
1. Xu Yuan-Zhen*; Zheng Shao-Long; Li Yun*; Au(I) /Brønsted Acid Relay-Catalyzed Benzannulation Reaction of Alkynylbenzaldehydes and Styrenes for the Synthesis of Substituted Naphthalenes, The Journal of Organic Chemistry, 2025, DOI: 10.1021/acs.joc.4c03186.
2. Yang Mei-Li; Wei Hong-Bo; Xu Yuan-Zhen*; Gao Jin-Ming*; Exploring the potential mechanism of Andrographis paniculata compounds against neurodegenerative diseases based on network pharmacology and molecular docking. Chinese Journal of Analytical Chemistry, 2025, 53(5) : 100514.
3. Wei Hong-Bo*; Zhan Fu-Rong; Zheng Ya-Qi; Xu Yuan-Zhen*; Design, synthesis and cell imaging of a new 3-thiolflavone fluorescent probe for biothiols, Spectrochimica Acta Part A: Molecularand Biomolecular Spectroscopy, 2024, 305: 123487.
4. Zou Huan-Huan; Yan Jia-Hang; Zhang Xiao-Cheng; Wu Xiao-Hui; Huo Ji-You; Xu Yuan-Zhen*; Xie Wei-Qing*; Asymmetric Synthesis of (+)-Vellosimine Enabled by a Sequential Nucleophilic Addition/Cyclization Process, Organic Letters, 2023, 25(46): 8215‒8219.
5. Fei Yuan-Ai; Hou Jun; Song Hui-Ying; Yang Mei-Li; Lei Pan; Ge Xia-Yu; Wei Hong-Bo*; Xu Yuan-Zhen*; Xie Wei-Qing*; Catalytic Asymmetric Friedel–Crafts Alkylation of Indole via In Situ Generated Indol-2-one, European Journal of Organic Chemistry, 2023, e202300122.
6. Xu Yuan-Zhen; Lei Pan; Fei Yuan-Ai; Hou Yi; Chen Gu-Zhou; Zhou Zhi-Qiang; Zou Huan-Huan; Wei Hong-Bo*; Xie Wei-Qing*; Catalytic asymmetric construction of C2-symmetric contiguous quaternary carbon centers enabled a concise synthesis of (−)-chimonanthidine and (−)-folicanthine, Tetrahedron Letters, 2022, 114: 154261.
7. Xu Yuan-Zhen; Wei Hong-Bo; Gao Jin-Ming*; Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia, Mini-Reviews in Medicinal Chemistry, 2021, 21(4): 520‒534.
8. Xu Yuan-Zhen; Tang Dan; Wang Jian-Ping; Wei Hong-Bo; Gao Jin-Ming*; Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons, Neurochemical Research, 2019, 44(4): 2619‒2630.
9. Xu Yuan-Zhen; Wei Hong-Bo; Wang Jian-Ping; Wang Wei-Wei; Gao Jin-Ming*; Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities, Bioorganic & Medicinal Chemistry, 2019, 27(11): 2209‒2219.
10.Xu, Yuan-Zhen; Wei, Hong-Bo; Chen, Jian-Jun; Gao, Kun*; A Thiol-inducible and Quick-response DNA Cross-linking Agent, Bioorganic & Medicinal Chemistry Letters, 2019, 29(2): 281‒283.
11. Xu, Yuan-Zhen; Gu, Xue-Yan; Peng, Shou-Jiao; Fang, Jian-Guo; Zhang, Ying-Mei; Huang, De-Jun; Chen, Jian-Jun*; Gao, Kun*; Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents, European Journal of Medicinal Chemistry, 2015, 94: 284‒297.
12. Xu Yuan-Zhen; Chen, Jian-Jun; Li Ya; Peng, Shou-Jiao; Gu Xue-Yan; Sun Meng; Gao Kun*; Fang Jian-Guo*; Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy, Organic & Biomolecular Chemistry, 2015, 13: 2634.
七、联系方式
通讯地址：西北农林科技大学（北校区）化学与药学院
邮编：712100
邮箱：yzxu@nwafu.edu.cn
