尹霞

发布时间:2019-03-25 浏览:


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一、个人简介

尹霞,女,回族,生于1986年9月,内蒙古包头人,中共党员,副教授,博士生导师。获教育部课程思政教学名师,陕西省课程思政教学标兵,陕西省线上线下混合式一流课程负责人,陕西省课程思政示范课负责人。受聘西北农林科技大学教学发展中心培训师,全国职业教育师资培训重点建设基地授课专家,陕西省杨陵区STEM指导专家,超星智慧教学研究院特聘专家。

二、学习与工作经历

1.学习经历

2005.09-2009.07 中国海洋大学,药学专业,学士。

2009.09-2014.07 中国科学院大学(中国科学院昆明植物研究所),药物化学,博士

2.工作经历

2014-2017,西北农林科技大学,讲师

2018-今,西北农林科技大学,副教授

三、研究课题

1. 激活沉默基因诱导黑蛋鸟巢菌次生代谢产物化学多样性和生物活性多样性的研究,国家自然科学基金青年项目(2016-2018)。

2. 桦褐孔菌速溶茶工业生产残渣脂溶性成分的开发利用,中央高校科研项目(2016-2018)。

3. 鸟巢菌中多靶点抗老年痴呆二萜的发现及作用,陕西省自然科学基金青年项目(2020-2022)。

4. 抗神经退行性疾病的灵芝新品种的引进,陕西省农业厅创新农业项目(2019-2021).

5. 两种大宗道地秦药志远和猪苓中抗老年痴呆功能物质及作用机制解析,陕西省自然科学基金面上项目(2024-2026).

6. 陕西大宗药食两用高等真菌功效成分解析及产品开发,陕西实验室,(2024-2026)

四、研究领域

1.高等真菌次生代谢产物结构-功能-作用机制系统解析

2.基于活性物质积累的高等真菌栽培模式

3. 药食同源中药材功能食品/保健品开发

五、开设课程

为本科讲授《有机化学A》、《有机化学I》,《有机化学II》《有机化学实验》,为研究生讲授《药物化学专论》。

六、主要科研成果与学术论文(近五年)

1. Xia Yin, Thi Mai Luong Tuong, Jun-Mian Tian, Gennaro Pescitelli, Jin-Ming Gao, Ganorbifates A and B from Ganoderma orbiforme, determined by DFT calculations of NMR data and ECD spectra. ChemComm, 2020, 56, 10195.

2. Xia Yin, An-An Yang, Jin-Ming Gao Mushroom toxins: chemistry and toxicology. J. Argic. Food. Chem. 2019, 67, 5053-5071.

3. Xia Yin, Chao Yu, Thi Mai Luong Tuong, Rong Wei Kou, An An Yang, Xin Chen, Wen Ji Wang, Yu Qi Gao, Jin Ming Gao, Structures of ganorbifates C-I, seven previously undescribed lanostanoids from the mushroom Ganoderma orbiforme, and insights of computed biosynthesis with DFT. Phytochemistry, 2022, 194, 113004. https://doi.org/10.1016/j.phytochem.2021.113004

4. Xia Yin, Jing Wei, Wei Wei Wang, Yu-Qi Gao, Marc Stadle; Rong-Wei Kou; Jin-Ming Gao* New cyathane diterpenoids with neurotrophic and anti-neuroinflammatory activity from the bird’s nest fungus Cyathus africanus. Fitoterapia, 2019, 134, 201-209.

5. Xia Yin, Jian-Zhao Qi, Yi-Xiao Li, Ze-An, Bao; Peng Du, Rong-Wei Kou, Wei-Wei Wang, Jin-Ming Gao, Terpenoids with neurotrophic and anti-neuroinflammatory activities from the cultures of the fungus Cyathus stercoreus. Nat. Prod. Res. 2020, DOI:10.1080/14786419.2020.1739043

6. Chao Yu, Chen-Yu Cao, Pei-dong Shi, An An Yang, De-Sen Huang, Xin Chen, Zi-Ming Chen, Jin Ming Gao, Xia Yin*, Highly oxygenated chemical constitutes and rearranged derivatives with neurotrophic activity from Ganoderma cochlear. J. Ethnopharm. 2022, 295, 115393.

7. An-An Yang, Ying Xiang Yang, Pei Dong Shi, Chao Yu, Yu Zhu Feng, Meng Ke Zhang, Liang, Xing Chen Yu Cao, Xia Yin*, Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme. Phytochemistry Lett. 2022, 48, 57-61.

8. Rong-Wei Kou, Bing Xia, Rui Han, Zhi-Qing Li,Jun-Ren Yang, Xia Yin,*,† Yu-Qi Gao,* and Jin-Ming Gao*. Neuroprotective Effects of a New Triterpenoid from Edible Mushroom on Oxidative Stress and Apoptosis through the BDNF/TrkB/ERK/CREB and Nrf2 Signaling Pathway in Vitro and in Vivo. Food & Function, 2022 Nov 2. doi: 10.1039/d2fo02854a.

9. Rong-Wei Kou, Shuang-Tian Du, Bing Xia, Qiang Zhang, Xia Yin*, Jin-Ming Gao*, Phenolic and steroidal metabolites from the cultivated edible Inonotus hispidus mushroom and their bioactivities. J. Agric. Food Chem. 2021, 69, 668-675.

10. Rong-wei Kou, Yu-qi Gao, Bing Xia, Jia-yun Wang, X. N. Kiu, Jing-Jiang Tang, Xia Yin; Jin-ming Gao Ganoderterpene A, a new triterpenoid from Ganoderma lucidum, attenates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells. J. Agric. Food Chem. 2021, 69, 12730-12740.

11. Rong-wei. Kou, Bing Xia, Zhi-Ju Wang, Jian. Ning Li, Jun-Ren Yang, Yu-Qi Gao, Xia Yin*, J. M. Gao, Triterpenoids and meroterpenoids from the edible Ganoderma resinaceum and their potential anti-inflammatory, antioxidant and anti-apoptosis activities. Bioorg. Chem. 2022, 121, 105689.

12. Rong-Wei Kou, Rui Han, Yu-Qi Gao, Ding Li, Xia Yin*, Jin-Ming Gao*, Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus, Phytochemistry, 2021, 184, 112647.

13. Rong-Wei Kou; Shuang-Tian Du; Yi-Xiao Li; Xi-Tao Yan; Qiang Zhang; Yu-Qi Gao; Xia Yin*; Jin-Ming Gao* Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus Cyathus africanus. J. Antibiotics, 2019, 72, 15-21.

14. Yi-Fan Guo, Yu-Zhu Feng , Jia-Yang Xu , Meng-Yue Dong , An-An Yang , Jin-Ming Gao *, Xia Yin * Ganoderma calidophilum-derived highly oxygenated lanostane triterpenoids: Multitarget neuroprotection through AMPK/mTOR/SIRT1 axis modulation and gut-brain axis crosstalk. Bioorg. Chem. 2025, 163, 108757.

15. Yi-fan Guo, Meng-ke Zhang, Jia-yang Xu, Meng-yue Dong, Xin Chen, Anan Yang, Jin-ming Gao * and Xia Yin * Ganoapplanilactone C from Ganoderma applanatum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish. Antioxidants, 2025, 14, 637.

16. Han Wu#, Meng-Yue Dong#, Yi-Fan Guo, Zheng-Bin Zong , Meng-Ke Zhang, Xin Chen,An-An Yang, Ming-Ming Cao*, Jin-Ming Gao*, Xia Yin* Lanostane triterpenoids and nor-abietane aromatic diterpenoid from Ganoderma applanatum and their neuroprotective activity. 2025, DOI: 10.26599/FSHW.2025.9250638.

七、联系方式

通讯地址:西北农林科技大学(北校区)化学与药学院(E214)

邮编:712100

电话:15829473668

邮箱:yinxiabb@outlook.com

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