一、个人简介
陈新,1987年10月生,江苏泰州人,副教授,硕士生导师。博士毕业于中国药科大学药物化学专业,导师为陆涛教授。2016年05月至今在西北农林科技大学化学与药学院工作。主要进行HDAC,激酶抑制剂的设计,合成及抗癌、抗阿尔兹海默病活性评价。申请三项专利,两项获得授权,参与研究的抗白血病临床候选药物FN-1501,已获得美国FDA孤儿药资格认定。
二、主持科研项目
1. 陕西省自然科学基础研究计划,2020JQ-284,基于二酮哌嗪骨架的HDAC6抑制剂的设计、合成及抗肿瘤活性研究,2020.01—2021.12,主持。
2. 国家自然科学基金青年基金,81903464,基于二酮哌嗪骨架的HDAC6抑制剂的设计、合成及生物活性研究,2020.01-2022.12,主持。
3. 天然药物活性组分与药效国家重点实验室开放课题,SKLNMKF202101,基于四氢-β-咔啉天然骨架的选择性HDAC6抑制剂的设计、合成及生物活性研究,2021.01—2022.12,主持。
三、近三年发表论文
1. Jiayun Wang, Feihu Gong, Ting Liang, Zhao Xie, Yingxiang Yang, Chenyu Cao, Jinming Gao, Tao Lu, Xin Chen*. A review of synthetic bioactive tetrahydro- β -carbolines: a medicinal chemistry perspective. European Journal of Medicinal Chemistry , 2021, 225:113815.(中科院一区,IF="6.514)
2. Guoliang Gong, Jianzhao Qi, Ye Lv, Shuai Dong, Chenyu Cao, Ding Li, Ru Zhao, Zhen Li*, Xin Chen*. Discovery of 1, 3-disubstituded 2, 5-diketopiperazine derivatives as potent class I HDACs inhibitors. Chem Pharm Bull , 2020, 68 (5), 466-472.
3. Xin Chen, Xinyang Chen, Raphael R. Steimbach, Tong Wu, Hongmei Li, Wenjia Dan, Peidong Shi, Chenyu Cao, Ding Li, Aubry K. Miller, Zhixia Qiu, Jinming Gao*, Yong Zhu*. Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity. European Journal of Medicinal Chemistry , 2020, 187:111950. (中科院一区,IF="6.514)
4. Xin Chen, Shuang Zhao, Hongmei Li, Xin Wang, Aixin Geng, Hao Cui, Tao Lu, Yadong Chen*, Yong Zhu*. Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors. European Journal of Medicinal Chemistry , 2019, 168:110-122. (中科院一区,IF="6.514)
5.Xin Chen*, Guoliang Gong, Ruihu Song, Mei Duan, Ruizhi Qiao, Yadong Chen, Yong Zhu. Design, synthesis and biological evaluation of novel benzoylimidazole derivatives as Raf and histone deacetylases dual inhibitors. Chem Pharm Bull , 2019, 67 (10), 1116-1122.
四、联系方式
E-mail:chenxin1888@nwsuaf.edu.cn
通讯地址:陕西省咸阳市杨陵区西北农林科技大学化学与药学院E214
邮编:712100